Clinical Evaluation of a Topical Dosage Form of<i> Alkanna orientalis </i>Root Extract in the Management of Pressure Lesions: A Pilot Cross-sectional Study

Background: Pressure lesions are chronic wounds causing the development of infection and inflammation into deeper structures finally necrosis. In Persian medicine, Alkanna orientalis (Boraginaceae) has been used for centuries as a naturally derived remedy managing lesions. A cross-sectional pilot clinical trial was conducted to assess wound healing effect an ointment made chloroform extract roots A. (CERAO). Methods: Sixty patients (36 men 24 women) diagnosed with bedsore staging 1-2 entered study one year. They were divided two groups control treatment equal proportions. The group received conventional from hospital, including irrigation serum, mupirocin, phenytoin ointments, gauze dressing. After rinsing cleansing normal saline, in intervention group, thin layer CERAO once daily four weeks. Clinical outcomes measured at weeks 2 4. Results: Recovery assessment carried out by measuring area, days epithelia formation, complete closure. difference between statistically significant (P-value &lt;0.05) terms mentioned criteria. recovery percentage 26.7% 60% groups, respectively. 16.7% population experienced wounds, while progression not observed. Conclusion: results this indicated that efficacy could be promising replacement pressure ulcers.